She initially started her career as a journalist and, after completing a Masterís degree in theology, she co-founded Stillpoint Publishing, where she led the editorial department. There she was responsible for producing books in the fields of holistic health and human consciousness.
Carolineís work as a medical intuitive began when she teamed up with C. Norman Shealy, a neurosurgeon, and began to do health readings of his patients. All the readings were done via a telephone and by only knowing the name and age of the patient, Caroline was able to produce profiles of their physical, psychological, emotional and family history.
Her research led her own to develop the discipline of energy anatomy, which links emotional, psychological, physical and spiritual stress with diseases. Her work in this area eventually led to the publication of the book, The Creation of Health, in conjunction with Norman Shealy.
Caroline and Norman developed an educational program to teach the principles of the Science of Medical Intuition and also fund research into the field. In 2003, Caroline created CMED (Caroline Myss Education), an educational institute with courses relating to personal development.
Carolineís books have been translated into numerous languages and are of universal appeal. She continues to teach workshops, run seminars, speak on radio shows and produce audio recordings.